Learn about Prilosec (Omeprazole) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Drug Review Package. 10903 New Hampshire Avenue Silver Spring, MD 20993 Ph. 1-888-INFO-FDA (1-888-463-6332) Contact FDA Prilosec OTC Product Monograph. 1. Introduction. Here are all of the details you need to better understand Prilosec OTC before recommending it to patients. PRILOSEC Packets are a once-a-day prescription treatment for heartburn and other symptoms of erosive esophagitis due to GERD for patients who have trouble swallowing pills. Omeprazole magnesium, the generic for Prilosec and Prilosec OTC, is a medication available as a prescription and over-the-counter drug. Prescription omeprazole treats stomach ulcers for 4 to 8 weeks. Consumer information about the OTC and prescription drug omeprazole (Prilosec, Zegerid Prilosec OTC, Zegerid OTC) used for treating acid-induced inflammation and ulcers of the stomach and duodenum, gastroesophageal reflux disease (GERD), heartburn, and Zollinger-Ellison Syndrome. Prilosec (Omeprazole) is used to treat symptoms of gastroesophageal reflux disease (GERD), erosive esophagitis and Zollinger-Ellison syndrome. I was prescribed Omeprazole after having Bariatric surgery (the sleeve). Three days after taking it I woke up with a sore neck. The next day the pain and soreness was in my shoulders and then upper back. Omeprazole, approved by the FDA, is available as a prescription and over-the-counter (OTC) drug used as a treatment for frequent heartburn. Learn about side effects, drug interactions, dosages, warnings, and more. Omeprazole can be used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, Zollinger-Ellison syndrome, and eosinophilic esophagitis.